Rogue Covid-19 strain N440K can cause reinfection, shows study. Researchers, including those from Kurnool Medical College, said a separate coronavirus novel, N440K, could cause infection.
According to them, this variant can escape the immune system and could cause infections in patients already diagnosed with Covid-19.
Investigators have studied the Kurnool case, which claims that the second case of Covid-19 reconstruction in India created by a different N440K, is one of the most powerful mutations of the virus. The study was published on a pre-print OSF research server.
Earlier, researchers at CCBB and Apollo hospitals in Hyderabad documented two cases of Covid-19 renewal in the city, but these were not related to the N440K. City scientists had said their work had shown that Covid-19 could cause re-infection regardless of whether the virus experienced a spike protein mutation or not.
Researchers at Kurnool Medical College, Kurnool, the Institute of Genomics and Integrative Biology, Delhi, and the Academy of Scientific and Innovative Research, Ghaziabad, found that the N440K has a population of over 33% in Andhra Pradesh.
A 44-year-old civil servant was diagnosed with Covid-19 on July 25, 2020. He was tested on August 2, 2020. However, he was also diagnosed on September 10, 2020, during a routine check-up. She has shown symptoms such as fever, cough, and malaise.
The research team comprising Pallavali Roja Rani, Mohammed Imran, Juturu Vijaya Lakshmi, Bani Jolly, Abhinav Jain, Avileli Surekha, Vigneshwar Senthivel, Pulala Chandrasekhar, Mohit Kumar Divakar, Damam Srinivasulu, Rahul C Bhojaar, Vharin PR, Scariaas, Sinib Scariaas identified 15 and 17 genetic variants in the genomes from two episodes of infection in the public service staff, respectively. Of the 14 genres they were common between the two episodes.
The study states that a close comparison of genetic variation and also a combination of antibody variants revealed the Spike N440K variant in genomes divided into two episodes of infection. Possibly these differences are also found in the case of the recurrence of diseases reported by a team to a health worker from North India.
Analysis shows that genomes divided into two categories fall under two different genomes, closely related to other genomes from Andhra Pradesh. The close genome similarity distinguishes itself from two episodes of infection but the discovery of different genes in the two genomes suggests that the patient contracted both diseases in the same area in Andhra Pradesh at two different times.
Recent studies examining the role of the novel coronavirus genetic variation in escaping viral response have illuminated viral mechanisms to prevent viral response and immune response. The N440K variant was reported to be resistant, the researchers reported.
The high prevalence of N440K in India and the findings presented in the study highlight the importance of analyzing the potential impact of a variety of addictive substances on regenerative and immune-mediated exposure, the researchers added.