Durgan : Can Fasting Lower Blood Pressure? Regular fasting is said to benefit the human body in many ways. From losing weight to body fat and supporting weight loss, fasting is linked to many benefits. But can fasting help high blood pressure patients by preventing their blood pressure from rising?
About half of adults in the United States have hypertension and it is a risk factor for heart disease and stroke, the leading causes of death in the US At Baylor College of Medicine.
Durgan who is an assistant professor of the anaesthesiology at Baylor also said that the previous studies from their lab have shown that the composition of the gut microbiota in animal models of hypertension, such as the SHRSP model, is different from that in animals with normal blood pressure.
The researchers also have shown that transplanting the dysbiotic gut microbiota from a hypertensive animal into a normotensive. It is the one having a healthy blood pressure that results in the recipient developing high blood pressure.
Durgan also said that this result told them that gut dysbiosis is not just a consequence of hypertension, but is actually involved in causing it.
Durgan along with his colleagues also drew on previous research showing that fasting was both one of the major drivers of the composition of the gut microbiota and also a promoter of the beneficial cardiovascular effects. These studies has however still not provided any kind of evidence connecting the microbiota and blood pressure.
The researchers had set up two groups and they said that working with the SHRSP model of spontaneous hypertension and the normal rats. One group had SHRSP and also the normal rats that were fed every other day, while the other group, had SHRSP and normal rats with the unavailability of the unrestricted food.
After around to nine weeks from when the experiment had started, the researchers has also observed that, as expected, the rats in the SHRSP control had higher blood pressure when compared to the normal control rats.
Durgan said that next, they had also investigated whether the microbiota was also a reason for the reduction of blood pressure that they have observed in the SHRSP rats that had fasted.
The researchers transplanted the microbiota of the rats that had fasted or they had fed without restrictions into germ-free rats, which have no microbiota of their own.
Durgan and colleagues used previous research showing that fasting was one of the major drivers of gut microbiota formation and a promoter of positive cardiovascular outcomes. These studies, however, did not provide evidence linking microbiota to blood pressure.
Working with the SHRSP model of high blood pressure and normal mice, the researchers established two groups. One group had SHRSP and normal mice fed daily, while the other group, called control, had SHRSP and normal mice with unrestricted access to food.
Nine weeks after the start of the study, the researchers found that, as expected, mice in SHRSP control had higher blood pressure compared to normal control mice. Interestingly, in the fasting group, SHRSP mice had significantly lower blood pressure compared with
Durgan said that next they had also investigated whether the microbiota was involved in lowering blood pressure that we had observed in mourning SHRSP mice.
Researchers are planting microbiota mice that have been fasting or feeding indefinitely in sterile mice, which do not have their own microbiota.
Durgan and his colleagues were pleased to note that sterile mice that received microbiota from SHRSP mice tended to have higher blood pressure than sterile mice that received microbiota from normal control mice, such as their accompanying microbiota sponsors.
Durgan said that It was very interesting to note that microbiota-free mice acquired microbiota from mice that listened to them significantly reduced blood pressure than mice that received microbiota from SHRSP control mice and that these results show that microbiota mutations caused by fasting were sufficient to regulate blood pressure which lowers fasting.